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A primetime battle on Monday Night Football features the (1-2) hosting the (2-1). This will be a battle between two offensive masterminds in Kyle Shanahan and Sean McVay. McVay is 4-7 against Shanahan head-to-head, and the 49ers will be without star left tackle (high-ankle sprain). Both teams are 1-2 against the spread this season.Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. San Francisco is favored by two points in the latest Rams vs. 49ers odds from Caesars Sportsbook, and the over/under is 42.5. Before making any 49ers vs. Rams picks, .The model, Brandon Thompson Jersey which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up. Now, the model has broken down Monday's matchup and just locked in its picks and MNF predictions. . Here are the and betting lines for Rams vs. Niners: Rams vs KeiVarae Russell Jersey . 49ers spread: San Francisco -2Rams vs. 49ers over/under: 42.5 pointsRams vs. 49ers money line: Los Angeles +110, San Francisco -130SF: 49ers are 5-0 ATS in their last five home gamesLAR: Rams are 4-1 ATS in their last five Monday gamesRams vs. 49ers picks: Featured Ryan Glasgow Jersey Game | San Francisco 49ers vs. Los Angeles Rams Moneyline Spread Total SF LAR San Francisco has a dominant and forceful defense. This unit owns an aggre sive defensive line that puts pre sure and gets after the quarterback. They are currently second in total yards allowed (227). Defensive lineman is the best player up front for the 49ers. Bosa can win with either speed or power while owning a relentle s motor.The Ohio State product has the speed to get around offensive tackles and gives maximum effort on each play. He's first on the team in sacks (4) and tackles for lo s (4) with 11 total tackles. Linebacker is a fast playmaker who runs sideline to sideline. The 2020 Pro-Bowl selection excels in coverage with outstanding instincts. Warner is fourth on the team in total tackles (16) with one pa s deflection. Los Angeles has plenty of star power Jessie Bates III Jersey on this roster. They have cornerback and defensive lineman leading the defensive unit. Ramsey is a shutdown corner who is a physical and reliable tackler. The five-time Pro Bowl selection has elite range and length to dispute opposing receivers and quarterbacks. The Florida State product has 16 total tackles, four pa s deflections, and one interception. Donald is a legitimate game wrecker for Los Angeles. The seven-time First-Team All Jonah Williams Jersey -Pro selection excels at getting past blockers and getting into the backfield. He is extremely powerful and manhandles opposing linemen. Donald has 10 total stops, two sacks, and three tackles for lo s. In his last outing, he logged six tackles and a sack.The model has broken down Niners vs. Rams on Monday Night Football from all angles. It is leaning Under on the total, projecting 40 combined points. The model also says one side of the spread hits well over 50% of the time. .So who wins 49ers vs. Rams on Monday Night Football? And which side of the spread hits more than 50% of the time? , and find out.